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two.2]decane core and defining the geometry in the exocyclic double bond. The activation energies of development of the vinyl-gold intermediates have been calculated and disclosed a silyl enol ether with the unprotected indole moiety as an acceptable precursor to the Toste cyclization. This six-step synthesis did not involve any nonstrategic redox
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Scientists have not long ago discovered and succeeded in synthesizing conolidine, a natural compound that reveals assure like a powerful analgesic agent with a more favorable protection profile. Although the specific mechanism of action continues to be elusive, it can be at this time postulated that conolidine may have numerous biologic targets. Pr